FIGURE 5.

The effect of oridonin on the reduction of cortical lesion volume. H&E staining was used to evaluate the cortical lesion volume. (A) Representative images of slice from sham, TBI + vehicle, and TBI + Ori groups. No cortical lesion was observed in the cortex from sham mice whereas clear cortex loss or free was observed in TBI mice cortex (marked with black lines). (B) Quantification of the cortical lesion volume and shown as a ratio of the lesion volume to the contralateral hemisphere volume. Less cortical damage was detected in the mice treated with oridonin compared with vehicle after TBI. n = 6/group. Data are presented as the mean ± SEM. ***p < 0.001 vs. sham group. ^##p < 0.01 vs. TBI + vehicle group.