Table 1.

Human Microarray Studies in PAH

Patient Population	Tissue	Microarray Platform	Analysis Method	Observations	Dataset
6 patients with PAH-SSc, 20 SSc patients without PAH and 9 healthy control subjects	EPCs	Affymetrix Human Exon 1.0 ST Array	A linear model was fitted to the log-transformed expression values using the limma package	2,175 genes were found differentially expressed between control and SSc PAH	GSE73674
15 patients with PAH (6 IPAH, 4 PAH CTD-PAH, 4 PAH secondary to CHD and 1 CTEPH) and 11 normal subjects	Lung	Affymetrix Human Gene 1.0 ST Array	A linear model was fitted to the log-transformed expression values using the limma package	12,834 genes were found differentially expressed in the PAH cohort compared with control subjects	GSE113439
6 patients with PAH and 3 healthy control subjects	PASMCs	Affymetrix Multispecies miRNA-4 Array	A linear model was fitted to the log-transformed expression values using the limma package	—	GSE108707
14 patients with PAH and 14 sex-/age- matching control subjects	PBMCs	Affymetrix GeneChip Human Gene 1.0 ST Array	A linear model was fitted to the log-transformed expression values using the limma package	2,624 genes were found differentially expressed between control subjects and patients with PAH	GSE131793

CHD = congenital heart disease; CTD-PAH = connective tissue disease-associated pulmonary arterial hypertension; CTEPH= chronic thromboembolic pulmonary hypertension; EPC = endothelial cells derived from circulating endothelial progenitor; IPAH = idiopathic pulmonary arterial hypertension; miRNA = micro-RNA; PASMC = pulmonary artery smooth muscle cell; PAH = pulmonary arterial hypertension; PBMC = peripheral blood mononuclear cell; SSc = systemic sclerosis.