Table 1.
Epidemiologic and disease characteristics of ON patients and healthy controls.
| IDON | AQP4 + ON | MOG + ON | HC | P-value | |
|---|---|---|---|---|---|
| Number of patients | 20 | 18 | 21 | 15 | – |
| Age at onset (years) | 34.50 ± 12.96 | 37.06 ± 12.95 | 35.81 ± 14.08 | 35.20 ± 12.39 | 0.945 |
| Gender (male:female) | 3:17 | 1:17 | 11:10 | 4:11 | 0.005 |
| Ocular pain (n, %) | 10 (50.0) | 15 (83.3) | 17 (81.0) | – | 0.036 |
| Disc swelling (n, %) | 8 (40.0) | 7 (38.9) | 7 (33.3) | – | 0.894 |
| Bilateral, ever (%) | 5 (25.0) | 7 (38.9) | 9 (42.9) | – | 0.461 |
| Recurrent ON onset (n, %) | 8 (40.0) | 18 (100.0) | 21 (100.0) | – | <0.001 |
| Median CSF white cell count (no./mm3) | 2.10 ± 4.12 | 6.89 ± 11.29 | 3.00 ± 3.67 | – | 0.095 |
| CSF protein (mg/L) | 288.82 ± 85.01 | 422.53 ± 132.88 | 304.42 ± 94.03 | – | <0.001 |
| CSF IgG level (mg/L) | 2.48 ± 0.96 | 3.55 ± 3.02 | 2.14 ± 0.64 | – | 0.05 |
| BCVA at first ON attacks in acute time (logMAR) | 1.85 ± 0.89 | 2.17 ± 0.79 | 1.82 ± 0.81 | – | 0.369 |
| BCVA recovery at last follow-up (logMAR) | 0.64 ± 0.67 | 1.00 ± 0.78 | 0.37 ± 0.51 | – | 0.015 |
ON, optic neuritis; AQP4: aquaporin-4; MOG, myelin oligodendrocyte glycoprotein; IDON, idiopathic demyelinated optic neuritis; HC, healthy controls; CSF, cerebrospinal fluid; MRI: magnetic resonance imaging; BCVA, best-corrected visual acuity. The bold values are used to indicate values with P < 0.05.