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. 2020 Nov 13;14:589042. doi: 10.3389/fnins.2020.589042

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Copyright © 2020 Zhou, Cui, Yan, Wang, Qu, Guo and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanisms and modulators of ferroptosis after ICH. Arrows indicate promotion, blunt- ended lines indicate inhibition, and the drugs in a green box are ferroptosis inhibitors. ICH, intracerebral hemorrhage; RBC, red blood cell; Tf, transferrin; TfR, transferrin receptor; AA, arachidonic acid; PE, phosphatidylethanolamine; PUFAs, plasma membrane polyunsaturated fatty acids; CoQ 10, coenzyme Q10; DFO, deferoxamine; DFP, deferiprone; NTA, nitrilotriacetic acid; EDTA, ethylenediaminetetraacetic acid; CQ, clioquinol; CP, ceruloplasmin; H2O2, hydrogen peroxide; OH, hydroxyl radical; Fer-1, ferrostatin-1; GPX4, glutathione peroxidase 4; Vit E, vitamin E; Vit C, vitamin C; FSP-1, ferroptosis suppressor protein 1; GSH, glutathione; GSSG, oxidized glutathione; Hb, hemoglobin; Lip-1, liproxstatin-1; NAC, N-acetylcysteine; LOX, lipoxygenase; and ROS, reactive oxygen species.