TABLE 1.

Comparison of different neuronal cell death types.

Types of cell death	Activators	Mediators	Inhibitors	Outcome
Ferroptosis	Iron, extracellular glutamine	Fe(II), ROS	Iron chelators, ferroxidase, antioxidants	Necrosis via lipid ROS
Necroptosis	Inflammatory factors	NLRP1/3, MKLK	Necrostatin-1, caspase-8	Necrosis via MKLK
Apoptosis	Inflammatory factors	Caspase 3,6,7,8,9	Bcl-2,zVAD	Phagocytosis
Oxytosis	Glutamate	System Xc-	BID inhibitors	Necrosis via glutamate
Pyroptosis	Inflammatory factors	Caspase-1, gasdermin D	NLRP1 inflammasome inhibitors	Inflammatory necrosis