TABLE 2.
Promising anti-ICH drugs that target ferroptosis.
| Drugs | Target | Impact on ferroptosis | References |
| Deferoxamine (DFO) | Iron | Function as iron chelator, depletes iron and prevent iron-dependent lipid peroxidation | Hu et al., 2019 |
| Deferiprone (DFP) | Iron | Function as iron chelator, depletes ferric iron and prevent iron-dependent lipid peroxidation | Garringer et al., 2016 |
| Minocycline | Iron | Function as iron chelator, depletes iron and prevent iron-dependent lipid peroxidation | Zhao et al., 2011a; Chang et al., 2017; Fouda et al., 2017; Yang et al., 2019, 2020 |
| Nitrilotriacetic Acid (NTA) | Iron | Function as iron chelator, depletes iron and prevent iron-dependent lipid peroxidation | Kose et al., 2019 |
| Ethylenediaminetetraacetic Acid (EDTA) | Iron | Function as iron chelator, depletes iron and prevent iron-dependent lipid peroxidation | Kose et al., 2019 |
| Clioquinol (CQ) | Iron | Function as iron chelator, depletes ferrous iron and prevent iron-dependent lipid peroxidation | Wang et al., 2016 |
| Cycliprox | Iron | Function as iron chelator, depletes iron and prevent iron-dependent lipid peroxidation | Stockwell et al., 2017 |
| VK-28 | Iron | Function as iron chelator, depletes iron and prevent iron-dependent lipid peroxidation | Li et al., 2017 |
| Ceruloplasmin | Iron | Function as ferroxidase, oxidizes toxic ferrous iron to less toxic ferric iron | Liu et al., 2019 |
| Ferrostatins-1 | ROS | Aggravates ROS generation and blocks lipid peroxidation | Zilka et al., 2017 |
| Liproxstatin-1 | ROS | Function as lipophilic antioxidants and blocks lipid peroxidation | Zilka et al., 2017 |
| GPX4 | ROS | Blocks lipid peroxidation | Zhang Z. et al., 2018 |
| Vitamin E | ROS | May inhibit lipoxygenases and blocks lipid peroxidation | Hinman et al., 2018 |
| Vitamin C | ROS | Inhibits lipid peroxidation | Tang and Tang, 2019 |
| Beta-carrotene | ROS | Blocks lipid peroxidation | Kose et al., 2019 |
| N-Acetylcysteine | System Xc- | Promotes cysteine import and cause GSH synthesis | Karuppagounder et al., 2018 |
| Dopamine | GPX4 | Function as neurotransmitter, blocks GPX4 degradation and blocks lipid peroxidation | Tang and Tang, 2019 |
| Selenium | GPX4, selenoproteins | Drives antioxidant GPX4 expression and blocks lipid peroxidation, increase abundance of selenoproteins. | Alim et al., 2019 |
| Zileuton | 5-LOX | Inhibits cytosolic ROS production as 5-LOX inhibitor and blocks lipid peroxidation. | Liu et al., 2015 |
| Ferroptosis Suppressor Protein 1 (FSP1) | CoQ10 | reduce CoQ10 to generate a lipophilic RTA that halts the propagation of lipid peroxides | Bersuker et al., 2019 |