. 2019 Jul 16;46(6):1341–1350. doi: 10.1007/s00068-019-01182-6

Table 2.

Baseline characteristics and association between variables of treatment of the infection and protocol

Treatment variable	Total (n = 71)	Protocol		P value	Missing
Treatment variable	Total (n = 71)	A (n = 39)	B (n = 32)	P value	Missing
Duration symptoms of infection before treatment				0.146^b	0
< 1 day	13	8	5
1–7 days	47	28	19
1–3 weeks	11	3	8
Number of debridements performed	2 (1–22)	2 (1–14)	3 (1–22)	0.209^c
Local Antibiotics with debridement^d	38	19	19	0.370^a	0
Closure after debridement					0
Primary closure	38	21	17	0.952^a
Secondary closure	24	17	7	0.952^a
Transplantation (flap/skin)	9	1	8	0.009^b
Vacuum therapy^e	29¹	12	17	0.057^a
Time to secondary closure after debridement, days^f	59 (6–540)	75 (9–540)	26 (6–214)	0.101^c
Antibiotic therapy					0
Duration i.v. antibiotic therapy	17 (7–116)	10 (7–116)	28 (7–110)	0.000^c
Duration oral antibiotic therapy	57 (0–119)	70 (0–112)	28 (0–119)	0.000^c
Duration total antibiotic therapy	80 (7–202)	81 (7–126)	64 (14–202)	0.235^c
Duration of rifampicin therapy	42 (0–116)	80 (7–116)	0 (0–93)	0.000^c

Bold P values are < 0.05 and considered significant

Data are presented as the number of cases or as median with the range in parenthesis

^a Pearson Chi-square

^bFisher’s exact

^cMann–Whitney U-test

^dLocal antibiotics consisted of either gentamicin-loaded beads, cement, or bioresorbable films in both protocols and were administered at assessment of the treating physician

^eOverlap with secondary closure and skin or flap transplantation

^fOutliers in wound closure in both groups were due to small skin defect with diminished wound-healing tendencies. Vacuum or antibiotic therapy was not indicated for the total duration needed for closure