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. 2020 Nov 13;10:582416. doi: 10.3389/fcimb.2020.582416

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Copyright © 2020 Chengalroyen, Jordaan, Seldon, Ioerger, Franzblau, Nasr, Warner and Mizrahi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Induction of iniBAC or recA bioluminescent reporter in response to antimycobacterial agents with unknown MoAs at concentrations ranging between 0.125-4× MIC, monitored over 9 days. For PiniB-LUX, INH was used as the positive control at a concentration of 0.39 µM (1× MIC); CIP was used as the negative control. The iniBAC response is shown for 127-09, 127-17, 127-21, 127-23, 127-13, 127-15, MN-6925, and the controls. For PrecA-LUX, CIP was used as the positive drug control at 3.13 µM (2× MIC), although concentrations in the range of 0.2–6.25 µM (0.125-4× MIC) all gave similar luminescence profiles; INH was the negative control. The recA response is shown for 127-11, 127-13 and the controls. RLU, relative luminescence unit.