Table 2.

Drug resistant mutants isolated against selected compounds.

Compound	MIC against H37Rv (µM)	MIC against SRM (µM)	Fold shift in SRM MIC (over H37Rv)	Mutation frequency
127-17R SRM-1	1.6–3.1	50	31×	2.0×10−7
127-21R SRM-1	1.6–3.1	50	31×	2.0×10−7
127-21R SRM-2	1.6–3.1	50	31×	2.0×10−7
127-23R SRM-1	3.1–6.3	50	16×	1.5×10−7
127-23R SRM-2	3.1–6.3	25	8×	1.5×10−7
127-13R SRM-1 127-13R SRM-2	1.6–3.1	12.5	8×	9.0×10−6
127-15R SRM-1 127-15R SRM-2	0.4–0.8	6.3	8×	2.5×10−6

MICs in 7H9 OADC media.