Table 4.

Evaluation of cross resistance of pyridine carboxamide analogues against KatG^S315T, inhA ^−15C→T and spontaneous drug resistant mutants.

Mtb strain	MIC (µM)
	H37Rv	KatGS315T	inhA −15C→T	127-17R SRM-1	127-21R SRM-2	127-23R SRM-2
Compound
127-09	1.6-3.1	25	6.3	6.3	12.5	3.1
127-17	1.6-3.1	50	25	50	50	50
127-21	1.6-3.1	50	12.5	25	50	50
127-23	3.1-6.3	50	25	50	50	50
INH	0.1	1.6	0.4	0.1	6.3	0.1

Tested against 127-17^R SRM-1 *^741R, 127-21^R SRM-2 ^S315R and 127-23^R SRM ^G285V.