Fig. 3. Substrate scope of the alcohol-surrogated Grignard-type reaction.

Reaction conditions: 1a (0.6 mmol), 2a (0.2 mmol), Ru(PPh₃)₃Cl₂ (5 mol %), ligand (5 mol %) and K₃PO₄ (2 equiv) in 2-MeTHF at 70 °C under N₂ atmosphere for 24 h. See Supplementary Information (SI) for details. Yield of isolated product was reported otherwise noted. a Ru-PNP-1 was used as catalyst. b ¹H NMR yield was determined using mesitylene as an internal standard. c The reaction was conducted at 100 °C, with 1a (0.8 mmol) and Ru-PNP-2 being the catalyst.