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. 2020 Nov 26;10:20635. doi: 10.1038/s41598-020-75025-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of HSA-Trx on neutrophil infiltration into lung in renal IR-mice. (A) Representative FACS dot plots showing the expression of CD11b and Ly-6G in BALF cells from mice at 8 h after sham operation or renal IR with or without HSA-Trx treatment. Percentage (%) of neutrophil (CD11b and Ly-6G double-positive cells) relative to total cells in BALF are indicated. (B) Immunostaining of pulmonary myeloperoxidase (MPO), which is a marker of neutrophils, at 8 h after renal IR. MPO (red)-stained lung sections were also treated with DAPI (blue). Original magnifications: × 100. Scale bars represent 100 μm. (C) CXCL1 and CXCL2 mRNA expression in lung at 4 and 8 h after renal IR were determined by real-time RT-PCR. (D) Renal mRNA and plasma level of IL-6 at 4 h after renal IR were determined by real-time RT-PCR and ELISA, respectively. Data are expressed as means ± SD (n = 4–6). *P < 0.05, **P < 0.01 compared with sham at each time point.