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. 2020 Nov 3;1(8):100130. doi: 10.1016/j.xcrm.2020.100130

Figure 2.

Figure 2

Anti-Stalk HA Antibodies as an Independent Correlate of Protection against Development of LRSs

(A and B) Binomial logistic regression of log10-transformed values of full-length and stalk HA: fitted curves of the relationship between log10 assay values and the probability of protection. A red dot indicates predicted protection of ~50%.

(C and D) Bars shows the proportion of SOTRs with LRSs according to defined antibody cutoffs. Each bar shows the number and percentage of SOTRs with LRSs among the total number of SOTRs with each antibody interval. ∗∗p = 0.02.

(E) Multivariate logistic regression model of factors correlated with LRSs at baseline on SOTRs with influenza infection. The model is adjusted by potential confounding factors to estimate the independent effect of antibody titers on disease progression and the serological predictors (Figure S3). The adjusted odds ratio (OR; 95% CI) for each assay and each level are shown.

(F) Linear regression of log10-values of anti-stalk antibodies measured by ELISA and anti-stalk antibodies with mediated ADCC activity measured in a bioreporter assay. ADCC experiments were performed in triplicate.