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. 2020 Nov 13;8:585995. doi: 10.3389/fcell.2020.585995

FIGURE 2.

FIGURE 2

ATF4 altered SBP and endothelial function-related factors in high-salt-induced hypertensive mice. (A) ATF4 altered SBP in high-salt-induced hypertensive mice. ND vs HSD, HSD vs OE, OE vs OC, *p < 0.05 and **p < 0.01. (B) ATF4 altered the expression of NO in high-salt-induced hypertensive mice. (C) ATF4 altered the expression of VEGF in high-salt-induced hypertensive mice. (D) ATF4 altered the expression of ANGI in high-salt-induced hypertensive mice. (E) ATF4 altered the expression of ET-1 in high-salt-induced hypertensive mice. Data are presented as mean ± SD; ns, no significance, *p < 0.05 and **p < 0.01, n = 6–8; statistical comparisons were performed using Student t-test or one-way analysis of variance (ANOVA). ATF4, activating transcription factor 4; KO, Atf4± mice; WT, wild-type mice; SBP, systolic blood pressure; NO, nitric oxide; VEGF, vascular endothelial growth factor; ANGI, angiotensin I; ET-1, endothelin-1; KO-ND, Atf4± mice with natural diet; KO-HSD, Atf4± mice with high-salt diet; ND, WT mice with natural diet; HSD, WT mice with high-salt diet; OE, Atf4 overexpression with high-salt diet; OC, Atf4 overexpression control with high-salt diet.