REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
CD107a-BV786	BD Biosciences	Cat # 563869; RRID:AB_2738458
CD137-BV650	BD Biosciences	Cat # 564092; RRID:AB_2738586
CD138-PE	BD Biosciences	Cat # 552026; RRID:AB_394323
CD14-FITC	BioLegend	Cat # 301804; RRID:AB_400086
CD152 (CTLA-4)-PE Cy5	BD Biosciences	Cat # 555854; RRID:AB_396177
CD19-APC-Cy7	BD Biosciences	Cat # 557791; RRID:AB_396873
CD19-BUV496	BD Biosciences	Cat # 564655; RRID:AB_2744311
CD1c-BV421	BD Biosciences	Cat # 565050; RRID:AB_2744319
CD20-BUV805	BD Biosciences	Cat # 612905; RRID:AB_2870192
CD22-BV510	BioLegend	Cat # 302526; RRID:AB_2721532
CD24-BV650	BD Biosciences	Cat # 563720; RRID:AB_2632388
CD25-BV605	BD Biosciences	Cat # 562660; RRID:AB_2744343
CD25-PerCPCy5.5	BD Biosciences	Cat # 560503; RRID:AB_1727453
CD267-APC	BioLegend	Cat # 311912; RRID:AB_2565423
CD269-PE-CF594	BioLegend	Cat # 357512; RRID:AB_2566531
CD26-APC	BioLegend	Cat # 302710; RRID:AB_10916120
CD26-PECF594	BD Biosciences	Cat # 565158; RRID:AB_2739085
CD27-BV711	BD Biosciences	Cat # 356430; RRID:AB_2650751
CD27-BV786	BD Biosciences	Cat # 563327; RRID:AB_2744353
CD3-BV421	BD Biosciences	Cat # 563797; RRID:AB_2744383
CD38-BV711	BioLegend	Cat # 303528; RRID:AB_2563811
CD3-FITC	BioLegend	Cat # 300306; RRID:AB_314042
CD45RA-Alexa Fluor 700	BD Biosciences	Cat # 560673; RRID:AB_1727496
CD45RO-BV605	BD Biosciences	Cat # 562791; RRID:AB_2744411
CD4-BUV496	BD Biosciences	Cat # 564652; RRID:AB_2744422
CD56-FITC	BioLegend	Cat # 362546; RRID:AB_2565964
CD62L-FITC	BD Biosciences	Cat # 555543; RRID:AB_395927
CD69-BV786	BD Biosciences	Cat # 563834; RRID:AB_2738441
CD69-PE Cy7	BD Biosciences	Cat # 557745; RRID:AB_396851
CD79a-PE-Cy7	BioLegend	Cat # 333510; RRID:AB_2564595
CD8-BUV805	BD Biosciences	Cat # 564912; RRID:AB_2744465
Foxp3-PE Cy7	Life Technologies	Cat # 25-4776-42; RRID:AB_10804638
Gamma-9-APC	BioLegend	Cat # 331310; RRID:AB_2057504
HLA-DR-PE-Cy5	BioLegend	Cat # 307608; RRID:AB_314686
ICOS-BUV395	BD Biosciences	Cat # 564777; RRID:AB_2738946
Ig kappa light chain-Alexa Fluor 700	BD Biosciences	Cat # 561319; RRID:AB_10611867
Ig lamda light chain-PerCPCy5.5	BioLegend	Cat # 316618; RRID:AB_2561512
IgD-BV605	BD Biosciences	Cat # 563313; RRID:AB_2738134
IgM-BUV396	BD Biosciences	Cat # 563903; RRID:AB_2721269
LIVE/DEAD Fixable Near-IR Dead Cell Stain Kit	ThermoFisher	Cat # L10119
PD-1-BV510	BD Biosciences	Cat # 563076; RRID:AB_2737990
PD-1-PE-CF594	Invitrogen	Cat # 61-2799-42; RRID:AB_2574598
TCF7-PE	BD Biosciences	Cat # 564217; RRID:AB_2687845
Biological Samples
Patient PBMCs from NT-001 trial	Ott et al., 2020	N/A
Healthy Donor PBMCs	Precision for Medicine	Cat # 93000-10M
Healthy Donor PBMCs	StemExpress	Cat # LE010F
Healthy Donor PBMCs	AllCells	https://www.allcells.com/tissue-products/leukopak/
Chemicals, Peptides, and Recombinant Proteins
CEF viral peptide pool	JPT	Cat # PM-CEF-E
Benzonase	Millipore Sigma	Cat # 70746
Assay peptides	Ott et al., 2020	N/A
MHC class I tetramers	Ott et al., 2020	N/A
Critical Commercial Assays
Pan T cell Isolation Kit, human	Miltenyi Biotec	Cat # 130-096-535
RNeasy Plus Micro Kit	QIAGEN	Cat # 74034
RNeasy Plus Mini Kit	QIAGEN	Cat # 74134
Qubit RNA HS Assay Kit	ThermoFisher	Cat # Q32855
KAPA Library Quantification Kit	Roche	Cat # KK4824
MiSeq Reagent Kit v2	Illumina	Cat # MS-102-2003
Fixation/Permeabilization Solution Kit	BD Biosciences	Cat # 554714
Foxp3/Transcription Factor Staining Buffer Set	eBioscience	Cat # 00-5523-00
AEC substrate-chromogen	BD Biosciences	Cat # 551951
IFN gamma Human ELISPOT Kit	Invitrogen	Cat # 88-7386-88
CD3 MicroBeads, human	Miltenyi Biotec	Cat # 130-050-101
Experimental Models: Cell Lines
Jurkat, Clone E6-1	ATCC	Cat # ATCC-TIB-152
A375	ATCC	Cat # ATCC-CRL-1619
293FT Cell Line	Thermo Fisher	Cat # R70007
Software and Algorithms
MiXCR (version 3.0.12)	Bolotin et al., 2015	N/A
FlowJo (version 10)	FlowJo Software (for Windows) Version 10. Becton, Dickinson and Company; 2019.	https://www.flowjo.com/
GraphPad Prism (version 7.01)	GraphPad Software, La Jolla California, USA	https://www.graphpad.com
R (version 3.5.1)	CRAN	https://www.r-project.org/
DescTools (R package)	Signorell et al., 2020	N/A
Philentropy (R package)	Drost et al., 2018	N/A
gplots (R package)	Warnes et al., 2015	N/A
Stats (R package)	R Core Team 2018	N/A
Survival (R package)	Therneau et al., 2000	N/A
Survminer (R package)	Kassambara et al., 2019	N/A