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. 2020 Nov 13;8:609430. doi: 10.3389/fcell.2020.609430

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Copyright © 2020 Cao, Jiang and Fan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanism of positive feedback stimulation of Ccnb1 and Mos mRNA translation by the MPF and MAPK cascade during mouse oocyte maturation. The short isoform of Ccnb1 is constitutively translated into cyclin B1 proteins in the GV stage-arrested oocytes, and form a pre-MPF with CDK1. At a threshold timepoint, the basal MPF and ERK1/2 activities trigger translational activation of the Ccnb1 long isoform and Mos mRNAs. Storage of MOS and cyclin B1 brings on a significant increase in CDK1 and ERK1/2 activity, thereby further boosting maternal mRNA translation, forming two entangled positive feedback loops (labeled red and green, respectively), eventually causing meiotic resumption and oocyte maturation.