TABLE 2.
MMAD, total deposited mass on the stages of the ACI, % recovery from the impactor and the trachea of the nebulizer load for the nebulizers and of the emitted dose for the pMDI and DPI, and mass of particles smaller than 5 μm of terbutaline (5 mg/2 mL) nebulized with PariLC Star and Aeroneb Go® nebulizers, salbutamol pMDI (100 μg/puff) and terbutaline Turbuhaler® DPI (500 μg/puff) for both ambient conditions and 37°C-humidified (HPTH: human physiological temperature and humidity), expressed as mean ± standard deviation.
| MMAD (μm) | Total deposited mass on the stages of the ACI (mg) (% of the nebulizer load or emitted dose) | % recovery from the trachea of the nebulizer load or emitted dose | Mass of particles < 5 μm | ||
| PariLC Star (1) + terbutaline | Ambient T and RH | 2.1 ± 0.3 | 2.3 ± 0.2 (43 ± 3%) | 6 ± 3% | 2.0 ± 0.2 (mg) |
| HPTH | 1.6 ± 0.1 | 2.5 ± 0.3 (47 ± 4%) | 6 ± 3% | 2.2 ± 0.2 (mg) | |
| Aeroneb Go® (2) + terbutaline | Ambient T and RH | 3.3 ± 0.1 | 3.9 ± 0.3 (76 ± 1%) | 6 ± 1% | 2.9 ± 0.1 (mg) |
| HPTH | 2.0 ± 0.2 | 3.9 ± 0.3 (74 ± 5%) | 10 ± 5% | 2.9 ± 0.2 (mg) | |
| Salbutamol pMDI (3) | Ambient T and RH | 3.1 ± 0.0 | 0.6 ± 0.0 (26 ± 1%) | 74 ± 1% | 15.8 ± 0.5 (μg/puff) |
| HPTH | 3.1 ± 0.1 | 0.6 ± 0.0 (28 ± 2%) | 72 ± 2% | 15.8 ± 1.3 (μg/puff) | |
| Terbutaline DPI (4) | Ambient T and RH | 3.7 ± 0.1 | 2.6 ± 0.2 (41 ± 3%) | 59 ± 3% | 82.8 ± 8.7 (μg/puff) |
| HPTH | 3.2 ± 0.1 | 1.5 ± 0.2 (25 ± 3%) | 75 ± 3% | 51.9 ± 3.3 (μg/puff) |
(1) jet nebulizer, (2) vibrating mesh nebulizer, (3) presurized metered-dose inhaler (pMDI), (4) dry powder inhaler (DPI).