TABLE 1.

Mastermind contains more content than HGMD, COSMIC, OncoKb, and ClinVar.

	Mastermind	HGMD		COSMIC		OncoKB		ClinVar
Genes	19,413	11,320	1	238	4	671	3	32,832	6
Variants	6,812,408	298,409	8	408,000	4	5,150	3	703,806	6
Germline variants	Yes	Yes		No		Yes		Yes
Somatic variants	Yes	No		Yes		Yes		Yes
Journals	33,126	2,600	2	N/A		Unknown		2,977
Full-text articles indexed	7,619,062	86,000	2	27,496	5	Unknown		70,538	7
Supplemental datasets indexed	2,599,660	N/A	2	N/A		Unknown		N/A
Update schedule	Weekly	Quarterly		Quarterly		Quarterly		Weekly
Free version content	Up to date	4 years old		Up to Date		<3 months old		Up to date
Interpretation criteria	ACMG/AMP	Own criteria		AMP		Own criteria		ACMG/AMP

Sources ¹http://www.hgmd.cf.ac.uk/ac/stats.php²https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429360/³https://www.oncokb.org/⁴https://cancer.sanger.ac.uk/cosmic/curation⁵https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323903/⁶https://www.ncbi.nlm.nih.gov/clinvar/submitters/⁷ftp://ftp.ncbi.nlm.nih.gov/pub/clinvar/tab_delimited/⁸https://digitalinsights.qiagen.com/wp-content/uploads/2020/10/hgmdstatistics_2020_3.pdf