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Adverse events of 46 patients treated with fruquintinib.
| Adverse events | Any grade | Grade ≥3 |
|---|---|---|
| Non-hematologic | ||
| Hypertension | 13 (28.3) | 3 (6.5) |
| Hand-foot syndrome | 17 (37.0) | 6 (13.0) |
| Proteinuria | 3 (6.5) | 0 (0.0) |
| Hepatotoxicity | 15 (32.6) | 2 (4.3) |
| Fatigue | 12 (26.1) | 1 (2.2) |
| Bleeding | 2 (4.3) | 0 (0.0) |
| Diarrhea | 6 (13.0) | 0 (0.0) |
| Hematologic | ||
| Leukopenia | 6 (13.0) | 2 (4.3) |
| Neutropenia | 5 (10.9) | 1 (2.2) |
| Thrombocytopenia | 11 (23.9) | 4 (8.7) |
| Anemia | 18 (39.1) | 2 (4.3) |
