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. 2020 Nov 13;10:541262. doi: 10.3389/fonc.2020.541262

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Copyright © 2020 Li, Cao, Huang, Wu, Chen, Wang and Xiong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MTA1 loaded exosomes enhanced gemcitabine mediated tumor growth inhibition in vivo. (1) Electron microscopy of exosomes (A). (2) WB assay tests markers of exosomes (B). (3) WB assay for MTA1 knockdown efficiency by siMTA1-loaded exosomes (Exo_siMTA1) (C). (4) Immunofluorescence (IF) assay for up taking of siMTA1-loaded exosomes by MCF-7 cells (D). (5) IF assay tested MTA1 knockdown efficiency by siMTA1-loaded liposomes (LIP_siMTA1) and Exo_siMTA1 (E). (6) Experiments process in vivo (F). (7) Tumor volume (1#: Exo + GEM, 2#: Exo_siMTA1, 3#: Exo_siMTA1 + GEM) (G, I). (8) Weight of mouse (H). (9) (J) Tumor growth inhibition rate (2#: Exo_siMTA1, 3#: Exo_siMTA1 + GEM). (10) H&E staining (K) and ki-67 staining (L).