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. 2020 Nov 13;11:598555. doi: 10.3389/fphar.2020.598555

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Copyright © 2020 Tsai, Xia and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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6-Gingerol exacerbates autophagy and enhances the accumulation of ROS and iron in A549 cells. (A) The autophagy electron microscope image of A549 cells, and yellow arrows marked the autophagy structure; (B) The activity of SOD in A549 cells; (C) The content of MDA in A549 cells; (D) The ROS fluorescence (DCF) of A549 cells; (E) The histogram of ROS content of A549 cells; (F) The iron concentration in A549 cells. Con: control, 20-Gin: 20 μM 6-Gingerol, 40-Gin: 40 μM 6-Gingerol, 80-Gin: 80 μM 6-Gingerol. Compared with the control group, *p < 0.05, **p < 0.01. Data are expressed as mean ± SD (n = 3).