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. 2020 Nov 13;11:598555. doi: 10.3389/fphar.2020.598555

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Copyright © 2020 Tsai, Xia and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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6-Gingerol regulates the expression of autophagy and ferroptosis related proteins in tumor. (A) The western blot analysis of USP14, Beclin 1, NCOA4, LC3 I, LC3 II, FTH1, TfR1, GPX4 and ATF4, Co-IP analysis of ubiquitination of K63 on Beclin one; (B) The densitometric analysis of the bands was presented as the relative ratio of USP14, Beclin 1, NCOA4, LC3 II/LC3 I, FTH1, TfR1, K63 ubiquitination on Beclin one to Beclin 1. Con: control, L-Gin: 0.25 mg/kg/day 6-Gingerol, H-Gin: 0.5 mg/kg/day 6-Gingerol. Compared with the control group, *p < 0.05, **p < 0.01. Data are expressed as mean ± SD (n = 3).