Table 2.
Results of cluster analysis
| no | Clusters name | Allergen molecules | Sensitization pattern | Biochemical name and function |
|---|---|---|---|---|
| Food clusters | ||||
| 132 | Soybean-nuts-fruits | Ara h 8, Cor a 1.0101, Cor a 1.0401, Gly m 4, Mal d 1, Pru p 1 | Cross reactivity | PR-10 proteins |
| 2 | Cod-walnut-sesame | Gad c 1, Jug r 1, Ses i 1 | Co- sensitization | Beta parva albumin- 2S albumin |
| 2 | Peanut-soybean | Ara h 3, Gly m 5, Gly m 6 | Cross-reactivity | Cupin- Beta conglycinin- Glycinin |
| 7 | Peanut | Ara h 2, Ara h 6 | Molecular spreading | Conglutin (2S albumin) |
| 7 | Hazelnut-peach | Cor an 8, Pru p 3 | Cross reactivity | nsLTP |
| 2 | Kiwi-chicken | Act d 1, Gal d 3 | Co- sensitization | Cystein protease, Ovotransferrin |
| Respiratory clusters | ||||
| 76 | House dust mite | Der f 1, Der f 2, Der p 1, Der p 2 | Cross reactivity and Molecular spreading | Cysteine protease, Neimann-Pick-type C2 protein |
| 150 | Bermuda-timothy | Cyn d 1, Phl p 1, Phl p 4 | Cross-reactivity and Molecular spreading | Beta expansins, Glycoprotein (Berberine bridge enzyme) |
| 53 | Birch-timothy-mercury | Bet v 2, Phl p 12, Mer a 1 | Cross reactivity | Profilin |
| 20 | Horse-mouse | Equ c1, Mus m 1 | Cross reactivity | Lipocalin |
| 3 | Dog-cat | Can f 3, Fel d 2 | Cross reactivity | Serum albumin |
| 223 | Alder-birch | Aln g 1, Bet v 1 | Cross reactivity | PR-10 proteins |
| 1 | Cattel-horse | Bos d 6, Equ c 3 | Cross reactivity | Serum albumin |
| 121 | Timothygrasspollen | Phl p 5, Phl p 6 | Molecular spreading | |
| 22 | Birch-timothy | Bet v 4, Phl p 7 | Cross reactivity | Polcalcin |
| 38 | Cypress-planetree | Cup a 1, Pla a 1 | Co- sensitization | Pectate lyase, Putative invertase inhibitor |
| Others | ||||
| 10 | Herring worm-cockroach | Ani s 3, Bla g 7 | Co- sensitization | Tropomyosin, Nitrile specifier |
| 1 | Latex | Hev b 5, Hev b 6.01 | Co- sensitization | Acidic protein, Hevein precursor |