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. 2020 Nov 13;14:571351. doi: 10.3389/fnana.2020.571351

FIGURE 4.

FIGURE 4

Sholl analyses of apical and basal dendrites of DIV 10 pyramidal cells of layers II/III and V/VI. (A) Sholl analyses of apical dendrites of pyramidal cells of layers II/III. Total intersections (mean with S.E.M.) are given in the insets. (B) Sholl analyses of basal dendrites of pyramidal cells of layers II/III showed a decrease of basal dendritic complexity in the ifenprodil/Ro25-6981 (Ifen/Ro25) treated neurons, but not NVP-AAM077/TCN201 (NVP/TCN) treated neurons between 50 and 200 μm from the soma. (C) Sholl analyses of apical dendrites of pyramidal cells of layers V/VI. (D) Sholl analyses of basal dendrites of pyramidal cells of layers V/VI showed a decrease of basal dendritic complexity in ifenprodil/Ro-6981 treated neurons, but not NVP-AAM077/TCN201 treated neurons between 50 and 150 μm distance from the soma. (B,D) ANOVA on ranks (AoR) versus control identified the significant reduction of total intersections in the ifenprodil/Ro25-6981 groups. The number of neurons analyzed per condition is given in Table 2.