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. 2020 Nov 18;38:101801. doi: 10.1016/j.redox.2020.101801

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© 2020 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Fig. 8 — Model of the study. The diagram reveals an m⁶A-dependent YTHDC2 regulation of SLC7A11 mRNA to modulate cystine uptake in LUAD cells. In our model, YTHDC2 destabilizes SLC7A11 mRNA via its m⁶A-reading YTH domain. METTL3-mediated m⁶A methylation of SLC7A11 mRNA at its 3′UTR is prerequisite for this process. YTHDC2 is frequently suppressed in LUAD; thereby its anti-tumor activity to impair cystine uptake and downstream antioxidant program is blocked. This model may explain a possible mechanism underlying tumorigenesis in LUAD.