Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 13;14:594975. doi: 10.3389/fncel.2020.594975

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Castellanos-Montiel, Chaineau and Durcan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Proteins are encoded by amyotrophic lateral sclerosis (ALS)-related genes affecting cytoskeletal dynamics. ALS2 is mainly implicated in the regulation of endosomal dynamics and it is also found at the growth cone of neurons where it promotes neurite outgrowth. Dynactin Subunit 1 (DCTN1) is involved in microtubules (MTs) anterograde and retrograde transport.Neurofilament light (NF-L), neurofilament heavy (NF-H), andperipherin (PRPH) are the main components of motor neuron (MN) intermediate filaments (IFs). Kinesin family member 5A (KIF5A) encodes a kinesin protein which mainly mediates anterograde transport along MTs. Profilin 1 (PFN1) is involved in the polymerization of actin filaments. Spastin (SPAST) is involved in MTs disassembly and therefore plays a key role in regulating MTs dynamics. Tubulin alpha 4a (TUBA4A) encodes for an α-tubulin subunit which is assembled within the MT filaments.