Table 2.

Dose-dependent changes in volumes of subcortical GM structures.

	N of structures	N of patients	Volume loss rate (%/Gy)	Volume loss rate (%/30 Gy)	95% confidence interval	p*
Amygdala	48	29	0.30	9.0	0.15–0.45	<0.01
Caudate nucleus	38	22	0.10	3.0	−0.22–0.42	0.74
Globus pallidus	35	22	1.37	41.2	0.68–2.07	<0.01
Hippocampus	42	28	0.16	4.9	0.02–0.31	0.03
Nucleus accumbens	45	25	0.32	9.5	0.13–0.50	<0.01
Putamen	44	29	0.81	24.3	0.42–1.20	<0.01
Thalamus	29	19	1.15	34.5	0.74–1.56	<0.01

^*Corrected for multiple testing.