Table 2.
Correlation between intensity and H-score of ALDH1 expression and clinicopathological characteristics in CRC
| Patients and tumor characteristics | H-score of ALDH1 expression No. (%) | P | Intensity of ALDH1 expression No. (%) | P | |||||
|---|---|---|---|---|---|---|---|---|---|
| Expression Pattern | <100 | 100-200 | <200 | Negative | Weak | Moderate | Strong | ||
| Cytoplasmic | 405(96.9) | 11(2.6) | 2(0.5) | 249(60) | 126(30) | 34(8) | 7(2) | ||
|
Gender
Male Cytoplasmic Female Cytoplasmic |
207(95.4) 196(98.5) |
9(4.1) 2(1) |
1(0.5) 1(0.5) |
0.09 | 126(58) 123(61) |
69(32) 57(29) |
17(8) 17(8) |
4(2) 3(2) |
0.88 |
|
Age
23-40 Cytoplasmic 41-60 Cytoplasmic >60 Cytoplasmic |
40(95.2) 170(98.3) 195(96.1) |
2(4.8) 3(1.7) 6(3) |
0(0) 0(0) 2(1) |
0.44 | 19(45.2) 100(57.8) 130(64.7) |
17(40.5) 56(32.4) 53(26.4) |
4(9.5) 16(9.2) 14(7) |
2(4.8) 1(0.6) 4(2) |
0.11 |
|
Tumor size
≤5 Cytoplasmic >5 Cytoplasmic |
276(95.8) 129(93.3) |
2(3.4) 9(5.9) |
1 (0.8) 1(0.8) |
0.001 | 163(59.4) 82(60.7) |
88(32) 37(27.4) |
20(7.3) 13(9.6) |
4(1.5) 3(2.2) |
0.66 |
|
Vascular invasion
Yes Cytoplasmic No Cytoplasmic |
56(96.6) 339(96.9) |
2(3.4) 9(2.6) |
0(0) 2(0.6) |
0.75 | 36(62.1) 207(59.5) |
15(25.9) 107(30.7) |
6(10.3) 28(8) |
1(1.7) 6(1.7) |
0.85 |
|
Neural invasion
Yes Cytoplasmic No Cytoplasmic |
79(98.6) 326(96.4) |
1(1.4) 10 (3) |
0(0) 2(0.6) |
0.79 | 53(72.6) 190(57.4) |
17(23.3) 104(31.4) |
3(44.1) 30(9.1) |
0(0) 7(2.1) |
0.07 |
|
Lymph node involvement
Yes Cytoplasmic No Cytoplasmic |
82(97.1) 256(96.6) |
3(2.1) 7(2.6) |
1 (0.8) 1(0.8) |
0.88 | 82(54.3) 166(26.9) |
53(35.1) 73(27.7) |
14(9.3) 20(7.6) |
2(1.3) 5(1.9) |
0.32 |
|
Metastasis
Yes Cytoplasmic No Cytoplasmic |
31(95.8) 374(96.8) |
1(4.2) 10(2.6) |
0(0) 2(0.5) |
0.55 | 16(66.7) 225(59.8) |
7(29.2) 122(29.8) |
1(4.2) 32(8.5) |
0(0) 7(1.9) |
0.93 |
|
Differentiation
Cytoplasmic Well Moderate Poor |
140(94.6) 237(97.9) 28(100) |
7(4.8) 4(1.7) 0(0) |
1(0.7) 1(0.4) 0(0) |
0.33 | 82(56.2) 145(61.2) 18(66.7) |
45(30.8) 73(30.8) 6(22.2) |
15(10.3) 16(6.8) 3(11.1) |
4(2.7) 3(1.3) 0(0) |
0.61 |
*The values are shown in bold are statistically significant.