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. 2020 Oct 31;43:101108. doi: 10.1016/j.molmet.2020.101108

Figure 2.

Figure 2

The loss of ChREBP in L.G6pc−/−livers aggravates hepatomegaly and leads to massive glycogen accumulation. Control and L.Chrebp−/− mice (pink bars) and L.G6pc−/− and L.G6pc−/−.Chrebp−/− mice (red bars) were fed a standard diet during 10 days after tamoxifen treatment. (A) Representative pictures of livers; bars represent 1 cm; no photo available of the livers of the L.Chrebp−/− mice, which were very similar in appearance and colour to those of the control mice. (B) Protein content of the liver (n = 6–7/group). (C) Liver weight and hepatic glycogen, G6P and glucose content (n = 6–8/group). (D) Relative mRNA expression of genes involved in glycolysis (Lpk and Gapdh) and the pentose phosphate pathway (G6pdh) (n = 5–6/group). Data are expressed as mean ± s.e.m. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 indicates significance compared to control mice; $p < 0.05, $$p < 0.01, $$$p < 0.001 indicates significance compared to L.G6pc−/− mice; £p < 0.05, ££p < 0.01 and £££p < 0.001 indicates significance compared to L.Chrebp−/− mice. See also Figure S3.