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Spheroids identified in the peripheral retina of patients with ALS. PAS-stained sections of the peripheral retina from (A) control (case 8) and (B) ALS (case 4). Several spheroids stained in deep purple are visible in the peripheral RNFL of the ALS patient (B, arrows). Abbreviations: RNFL = retinal nerve fiber layer; GCL = ganglion cell layer; IPL = inner plexiform layer; INL = inner nuclear layer; OPL = outer plexiform layer; ONL = outer nuclear layer. Scale bar = 100 µm.
