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Spheroids identified in the peripapillary retina of patients with ALS. PAS-stained sections of the peripapillary retina from (A) control (case 7) and (B) ALS (case 2). The boxed region in (B) is expanded in (C). Spheroids stained in deep purple were observed in the peripapillary RNFL of the ALS patient (C; arrow). Abbreviations: RNFL = retinal nerve fiber layer; LC = lamina cribrosa. (A, B) Scale bar = 100 µm; (C) scale bar = 50 µm.
