Table 2.
Retinal Spheroids and Axon Pathology in Patients With ALS Compared With Controls
| Exact Wilcoxon Matched-Pairs Signed-Rank Test | ||||
|---|---|---|---|---|
| Median | IQR | S | P Value | |
| PAS-positive spheroids per mm2: Total RNFL | ||||
| Control | 0.3 | 1.8 | ||
| ALS | 2.6 | 1.8 | 21.5 | .0273 |
| PAS-positive spheroids per mm2: Peripapillary RNFL | ||||
| Control | 0.0 | 0.0 | ||
| ALS | 4.6 | 7.1 | 12.0 | .0469 |
| PAS-positive spheroids per mm2: Peripheral RNFL | ||||
| Control | 0.0 | 2.9 | ||
| ALS | 2.1 | 4.4 | 6.5 | >0.05 |
| PAS-positive spheroids per mm2: Central RNFL | ||||
| Control | 0.0 | 0.0 | ||
| ALS | 0.0 | 0.0 | 0.5 | >0.05 |
| P-NF–positive spheroids per mm2 | ||||
| Control | 0.0 | 0.0 | ||
| ALS | 1.3 | 0.8 | 22.5 | .0039 |
| NP-NF–positive spheroids per mm2 | ||||
| Control | 0.0 | 0.0 | ||
| ALS | 0.0 | 0.0 | 1.5 | >0.05 |
| Mean pixel intensity of P-NF (AU) | ||||
| Control | 7328.9 | 2711.5 | ||
| ALS | 22365.4 | 5154.7 | 27.5 | .0020 |