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. 2020 Jun 1;15(4):155–160. doi: 10.1016/j.joto.2020.04.001

Table 1.

Summary of BPPV supplementary treatments performed in human patients. HRT: Hormonal replacement therapy.

Compound Study Results Authors
Estrogen A retrospective population study to analyze the incidence of BPPV and protective factors against it. The incidence of BPPV is significantly lower in estrogen-treated patients due to menopausal syndromes. Liu et al., (2017).
Estrogen + Progesterone A prospective study of 10 female patients diagnosed with BPPV and treated with HRT. The cessation of treatment with oral contraceptives keeps vertigo under control. Giacomini et al., (2006).
Vitamin D A longitudinal study of patients with low levels of vitamin D (<20 ng/mL), 27 treated/27 not treated with 50.000 IU cholecalciferol weekly + maneuvers for two months. The group treated with vitamin D decreased BPPV episodes. They remained stable and unchanged during the study period compared to the untreated group. Sheikhzadeh et al., (2016).
Vitamin D A prospective study of 40 patients with BPPV; 16 out of them were treated with vitamin D due to their low levels (unspecified dose). Supplementation decreased BPPV episodes, but the results were not statistically significant. Cupido et al., (2018).
Bisphosphonates
Raloxifene
Calcitonin
Teriparatide
A retrospective study of osteoporosis treated in 260 women with and BPPV, aged 51–80 years. A negative association between BPPV and treated osteoporosis in women aged 51–60 years. Mikulec et al., 2009.
Methylprednisolone A pilot study of 9 patients with persistent posterior canal BPPV treated intratympanically (two weekly doses of 0.3–0.4 mg/mL to 40 mg/mL) before repeating repositioning procedures. 7 out of 9 patients were relieved of their symptoms and did not exhibit positional nystagmus after 1 or 2 repositioning maneuvers. Perez et al., (2016).
Dexamethasone 2 cases with intractable posterior BPPV treated with 3.3 mg in 1 ml solution Relief of symptoms and absence of nystagmus in positional maneuvers. Kelkar et al., (2018).