Table 1.
The role and mechanism of ncRNA interacting with OCT4 in CSCs
| Non-coding RNA (ncRNA) | Category | Mechanism of regulating cancer stem cells (CSCs) | The role in CSCs |
|---|---|---|---|
| NETA1.1 | lncRNA | Binds to OCT4 | Invasion and growth of CSCs |
| CCAT2 | lncRNA | Overexpressed and upregulates OCT4-PG1 | Aggressiveness of CSCs |
| MALAT1 | lncRNA | Inhibits miR-20b-5p | Maintain stemness |
| AK055347 | lncRNA | Overexpressed in CSCs | Invasion and proliferation |
| AK028326 | lncRNA | Binds to Oct4 | Maintain stemness |
| Lnc-CRCMSL | lncRNA | Inhibits interaction between HMGB2 and OCT4 | Anti-metastatic |
| H19 | lncRNA | Changes chromatin conformation and epigenetic modification | Maintain stemness |
| miR-302 | miRNA | Inhibits NR2F2 | Maintain stemness |
| miR-145 | miRNA | Binds to 3’UTR of OCT4 | Differentiation |
| Lnc-DYNC2H1-4 | lncRNA | Binds to miR-145 | Maintain stemness |
| ROR | lncRNA | Increases miR-145 and targets OCT4 directly | Inhibition of CSCs |
| miR-1246 | miRNA | Activates Wnt/β-catenin | Maintain stemness |