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Netrin-1 dependence receptors. (a) Schematic structure of DCC and UNC5 cytoplasmic and extracellular domains. (b) Netrin-1 binding to DCC-DCC and DCC-UNC5 complexes, promoting neuronal attraction and repulsion respectively. (c) Apoptosis promoted by DCC receptor in the absence of netrin-1. (d) Apoptosis promoted by UNC5 receptor in the absence of netrin-1.
