Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Overview of netrin-1 effects in the context of normal physiology and atherosclerosis. (a) Endothelial-derived netrin-1 interacts with UNC5b receptors on the monocyte surface, causing chemorepulsion. (b) In atherosclerosis, pro-inflammatory cytokines act on endothelial cells to downregulate expression of endothelial-derived netrin-1, as well as upregulate endothelial cell adhesion molecules, the resultant effect of both being increased monocyte recruitment to the plaque.
