Figure 6.

Proposed model for the protective role of netrin-1 in endothelium. In the absence of netrin-1, pro-inflammatory stimuli induce the TLR4 cascade leading to transmigration of NF-κB to the nucleus, promoting expression of pro-inflammatory cytokines and adhesion molecules. The protective effects of netrin-1 are believed to be exerted through inhibition of IKK activation and IκB phosphorylation and degradation, via the UNC5b receptor, thereby preventing nuclear translocation. Image adapted from Mehlen et al.⁴⁵