Table 1.

Clinical recommendations, Head and Neck Unit.

1) Baseline symptoms evaluation	Recommended
2) EUS-FNAB	Recommended
3) EUS-FNAC	Recommended
4) Ultrasound imaging	Recommended
5) Contrast-enhanced magnetic resonance imaging	Recommended
6) Contrast-enhanced computed tomography	Recommended
7) Positron emission tomography	Recommended only in metastatic setting
8) Immunochemistry (CK, p63, GATA3, androgen receptor)	Recommended
9) Radical parotidectomy en block with infiltrated structures modified Radical Neck dissection (level Ib-V)	Recommended in parotid gland carcinoma
10) Sialoadenectomy en block with infiltrated structures Modified radical neck dissection (livel I-V)	Recommended in sub-mandibular carcinoma
11) Adjuvant radiotherapy +/- concomitant chemotherapy (IMRT)	Recommended (in case of T3-T4, high grade, close/positive margin, perineural invasion, Nodal status positive, ENE+)
12) Neoadjuvant chemotherapy	Not recommended TPF schedule Considered Carboplatin-Paclitaxel schedule
13) Molecular profiling in metastatic setting:EGFR expression, RAS mutation, PDL1 expression, NOTCH mutation	Recommended for personalized therapy

EUS-FNAB: endoscopic ultrasound guided-fine needle aspiration biopsy; EUS-FNAC: endoscopic ultrasound guided-fine needle aspiration cytology; ENE: extranodal extension.