Table 2.
Sub-maximum CPET parameters.
Control (n = 18) | Ipc-PH (n = 19) | Cpc-PH (n = 27) | |
---|---|---|---|
Time between RHC and sub-maximum CPET, median (IQR), days | 51 (10–107) | 19 (8–34) | 15 (8–23) |
ETCO2 (mmHg) | 35 ± 5 | 38 ± 4 | 34 ± 4b |
Rest SpO2 (%) | 97 ± 1 | 95 ± 2a | 95 ± 2a |
Peak SpO2 (%) | 95 ± 2 | 90 ± 3a | 90 ± 4a |
RER | 1.03 ± 0.1 | 1.03 ± 0.1 | 1.04 ± 0.1 |
VE/VCO2 | 31 ± 10 | 31 ± 7 | 41 ± 11a,b |
Delta ETCO2 (mmHg) | 1.9 ± 5.0 | −0.2 ± 4.0 | −3.6 ± 3.4a,b |
GXCAP (mL*mmHg) | 611 ± 247 | 541 ± 141 | 348 ± 137a,b |
OUES (% predicted) | 102 ± 22 | 79 ± 20a | 61 ± 15a,b |
O2 pulse (mL/O2/beat) | 180 ± 102 | 101 ± 22a | 98 ± 36a |
Sub-maximum VO2 (% predicted) | 98 ± 18 | 64 ± 11a | 60 ± 18a |
Extrapolated maximum VO2(% predicted) | 121 ± 44 | 69 ± 18a | 62 ± 21a |
Note: Data presented as no. (%) or mean ± SD unless otherwise stated.
CPET: cardiopulmonary; Ipc-PH: isolated post-capillary pulmonary hypertension; Cpc-PH: combined pre-and post-capillary pulmonary hypertension; RHC: right heart catheterization; ETCO2: end tidal carbon dioxide; SpO2: peripheral oxygen saturation; RER: respiratory exchange ratio; VE/VCO2: ventilatory efficiency; GXCAP: gas exchange derived pulmonary vascular capacitance; OUES: oxygen uptake efficiency slope; VO2: oxygen consumption.
ap-value < 0.05 vs. controls.
bp-value < 0.05 vs. Ipc-PH.