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. 2020 Nov 26;10:20598. doi: 10.1038/s41598-020-75833-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The impact of cytoskeleton disorganisation on SMYD3 cellular distribution. (a) Micrographs of SMYD3-HA-Flag localisation in C2C12 cells treated with drugs targeting actin polymerisation (Latrunculin A or Latrunculin B). (b) Quantification of increased nuclear localization of SMYD3-HA-Flag upon drug treatment of cells plated on non-patterned substrates. A Kruskal–Wallis test was performed. (c) Quantification of increased nuclear localization of SMYD3 upon drug treatment of cells plated on square (green), or rectangle (1:5, blue, 1:8, grey) patterns. Pattern area = 1800 μm². Cells were treated with Y-27632 or blebbistatin (Blebb) or Latrunculin (LatA or LatB). A Kruskal–Wallis test was performed between conditions with identical aspect ratios. n = number of individual cells measured. *p < 0.05, **p < 0.01, ***p < 0.001, n.s. not statistically significant.