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ILCs in melanoma. During melanoma progression, different ILC subsets maintain active crosstalk, resulting in either antitumoral or protumoral responses, not only by direct action on tumor cells but also by acting on other ILCs (left). Moreover, ILCs modulate CD4+ T-cell activity and, thus, influence the adaptive immune response through MHC class II. MHC—Major histocompatibility complex.
