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Nucleoside transporters in mammalian cells. CNTs facilitate the Na+-dependent transport while ENTs are bi-directional and Na+-independent transporters, facilitating the uptake of different anticancer drugs [27,28,29,30]. Of note, hENT-1 (es) is NBMPR-sensitive and the figure shows its crystalized structure [30]. Acronyms: 5-HT, 5-hydroxy-tryptamine; NBMPR, nitrobenzylmercaptopurine ribonucleoside.
