Figure 2.

Association of hENT-1 expression levels and survival. Bar graph summarizing the survival data of PDAC patients in studies supporting the role of hENT-1 as a predictive biomarker for the efficacy of gemcitabine. The clinicopathological and treatment details of studies before 2014 [41,42,43,44,45,46,47,48] were reviewed systematically by Nordh et al. [49], while a more recent systematic review by Bird et al. [51] evaluated also the data from the European Study Group for Pancreatic Cancer 3 (ESPAC-3) trial [50]. n = number of patients, p = statistical p values.