Table 3.

Prevalence of familiar hypercholesterolemia in premature coronary artery disease according to different studies.

	N	Inclusion Criteria	Clinical Presentation of CAD	Clinical Diagnosis (DLCN Probable-Definite) (%)	Genetic Diagnosis (%)
Amor-Salamanca et al. [29]	103	≤65 years old and LDLc ≥160 mg/dL	STEMI, NSTEMI and unstable angina	27.2%	8.7%
Cui et al. [30]	225	≤55 years old in men and ≤60 in women	Myocardial infarction (STEMI and NSTEMI)	5.3%	4.4%
De Backer et al. [31], Subanalysis of premature CAD	2212	<60 years old	ACS, acute myocardial ischemia or procedure: coronary artery bypass grafting or percutaneous coronary intervention)	15.4%	Not evaluated
Koivisto et al. [32]	90	≤45 years old	Symptomatic CAD (myocardial infarction and effort-induced angina pectoris)	Not evaluated	9%
Li et al. [33], Subanalysis of premature CAD	889	≤55 years old in men and ≤60 in women	Myocardial infarction (STEMI and NSTEMI)	7.1%	Not evaluated
Nanchen et al. [28] Subanalysis of premature CAD	1451	<55 years old in men and <60 in women	ACS (not specified whether STEMI, NSTEMI or unstable angina)	4.8%	Not evaluated
Pang et al. [34]	175	<60 years old	ACS, myocardial revascularization and angina pectoris	14.3%	Not evaluated
Pirazzi et al. [27]	49	<50 years old in men and <55 in women	Myocardial infarction (STEMI or NSTEMI), unstable angina, stable angina or atherosclerosis, spasm angina and other diagnosis (non- atherosclerotic)	16.7%	6.1%
Wald et al. [35]	231	≤50 years old	STEMI and NSTEMI	Not evaluated	1.3%
Yudi et al. [36]	210	≤55 years old in men and ≤60 in women	ACS, angina, unstable angina, STEMI and NSTEMI	1.4%	Not evaluated
Lorca et al. (this study).	56	<55 years old in men and <60 females in women	STEMIConfirmed by coronary angiogram	1.8%	1.8%

ACS: acute coronary syndrome; CAD: coronary artery disease; DLCN: Dutch Lipid Clinic Network; STEMI: myocardial infarction with ST elevation; NSETMI: myocardial infarction without ST elevation.