Table 2.
Effect of AE on serum biochemical parameters in the experimental mice.
| Serum Biomarkers | ND | HD | GE300 | AE100 | AE300 |
|---|---|---|---|---|---|
| ALT (U/L) | 44.9 ± 5.9 b | 196.8 ± 108.5 a | 74.9 ± 22.3 b | 55.2 ± 20.7 b | 41.4 ± 9.3 b |
| AST (U/L) | 56.9 ± 6.5 b | 114.4 ± 61.3 a | 86.3 ± 18.9 b | 71.6 ± 12.1 b | 69.6 ± 6.8 b |
| TC (mg/dL) | 127.0 ± 9.0 c | 220.0 ± 21.0 a | 168.0 ± 22.0 b | 176.0 ± 9.0 b | 162.0 ± 14.0 b |
| TG (mg/dL) | 126.0 ± 13.0 b | 247.0 ± 60.0 a | 118.0 ± 17.0 b | 123.0 ± 20.0 b | 124.0 ± 9.0 b |
| GLU (mg/dL) | 256.0 ± 39.1 c | 460.3 ± 69.6 a | 316.1 ± 38.1 bc | 320.0 ± 20.4 b | 303.5 ± 38.1 bc |
| HDL-C (mg/dL) | 98.8 ± 6.8 c | 159.8 ± 12.0 a | 138.1 ± 15.4 b | 140.9 ± 19.6 b | 142.6 ± 8.3 ab |
| LDL-C (mg/dL) | 14.5 ± 1.9 b | 35.2 ± 8.2 a | 17.3 ± 3.5 b | 20.2 ± 3.4 b | 18.1 ± 1.8 b |
| Leptin (pg/mL) | 225.2 ± 20.9 c | 484.6 ± 60.4 a | 421.3 ± 101.2 a | 433.5 ± 76.9 a | 318.6 ± 14.1 b |
Mice were fed a high-fat diet and orally administered GE (300 mg/kg b.w) or an AE (leaf extract) at low dose (100 mg/kg b.w) or high dose (300 mg/kg b.w) for 8 weeks. ALT, alanine aminotransferase, AST, aspartate aminotransferase, TC, total cholesterol, TG, triglycerides, GLU, glucose, HDL-C, high-density lipoprotein cholesterol, LDL-C, low-density lipoprotein-cholesterol. ND, normal diet, HD, high-fat diet, GE300, high-fat diet + Garcinia 300 mg/kg b.w, AE100, high-fat diet + 100 mg/kg b.w, AE300, high-fat diet + 300 mg/kg b.w. Values are expressed as mean ± SEM, n = 10. The varying superscript letters indicate a statistically significant difference among the groups by Duncan’s test of ANOVA, p < 0.05.