Table 3.
Serum concentrations of infection markers in patients with different types of JIA and controls. Results are presented as mean (median) ± standard deviation.
| EBV Infection Marker | JIA (n = 44) | Control (n = 44) |
p-Value | |||
|---|---|---|---|---|---|---|
| Oligoarthritis (n = 21) |
Polyarthritis RF+ & RF− (n = 15) |
ERA & Psoriatic Arthritis (n = 8) |
||||
| EA (U/mL) |
IgM | 0.63 (0.50) ± 0.31 |
0.76 (0.72) ± 0.35 |
0.73 (0.46) ± 0.58 |
0.68 (0.64) ± 0.34 |
0.67 |
| IgA | 0.37 (0.39) ± 0.16 |
0.31 (0.3) ± 0.12 |
0.26 (0.27) ± 0.10 |
0.34 (0.29) ± 0.20 |
0.16 | |
| IgG | 0.24 (0.19) ± 0.17 |
0.23 (0.18) ± 0.15 |
0.17 (017) ± 0.05 |
0.2 (0.14) ± 0.17 |
0.20 | |
| EBNA-1 (U/mL) |
IgA | 0.11 (0.09) ± 0.05 |
0.11 (0.09) ± 0.05 |
0.10 (0.1) ± 0.04 |
0.10 (0.07) ± 0.06 |
0.10 |
| IgG | 0.42 (0.43) ± 0.28 |
0.57 (0.67) ± 0.28 |
0.36 (0.27) ± 0.31 |
0.46 (0.44) ± 0.31 |
0.27 | |
| IgM | 0.18 (0.15) ± 0.07 |
0.20 (0.16) ± 0.08 |
0.19 (0.17) ± 0.10 |
0.20 (0.17) ± 0.13 |
0.20 | |
| VCA (U/mL) |
IgA | 0.23 (0.17) ± 0.19 |
0.20 (0.18) ± 0.13 |
0.29 (0.12) ± 0.40 |
0.24 (0.17) ± 0.21 |
0.69 |
| IgG | 1.03 (1.09) ± 0.50 |
0.10 (0.98 ± 0.54 |
0.87 (0.85) ± 0.51 |
0.91 (0.95) ± 0.54 |
0.27 | |
| Viral load | Copy number/µL | 0.37 (0) ± 0.67 |
0.16 (0) ± 0.57 |
0.58 (0) ± 0.16 |
0.48 (0) ± 0.81 |
0.64 |
| Copy number/µg DNA | 4.37 (0) ± 7.97 |
1.00 (0) ± 3.38 |
4.19 (0) ± 7.91 |
4.77 (0) ± 7.94 |
0.59 | |
| Copy number/100,000 cells | 2.28 (0) ± 5.26 |
0.66 (0) ± 2.23 |
2.77 (0) ± 5.22 |
3.15 (0) ± 5.24 |
0.59 | |
| DNA ng/µL | 90.49 (84.8) ± 28.34 |
104.09 (90.3) ± 34.14 |
123.53 (126.69) ± 33.07 |
94.98 (89.61) ± 29.23 |
0.25 | |
EA—early antigen; EBNA-1—Epstein-Barr nuclear antigen 1; ERA—enthesitis-related arthritis; JIA—juvenile idiopathic arthritis; RF+—rheumatoid factor positive; RF−—rheumatoid factor negative; VCA—viral capsid antigen.