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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced podocyte injury, mediated by the increased expression of CD147. In healthy podocytes, CD147 is seldom expressed. In podocytes damaged by the overexpression of the renin–angiotensin–aldosterone system, CD147 expression is increased, even though a disintegrin and metalloprotease 17 (ADAM17) expression is also modulated by Ang II-mediated AT1R activation. SARS-CoV-2 can enter the podocyte and induce podocytopathy.
