Table 1.
A list of alternative names for equivalent CCR4–NOT complex subunits from Saccharomyces cerevisiae (baker’s yeast), Homo sapiens (human) and Drosophila melanogaster (fruit fly).
| Saccharomyces Cerevisiae | Homo Sapiens | Drosophila Melanogaster | Function |
|---|---|---|---|
| NOT1/CDC39 | CNOT1 | NOT1 | Scaffold |
| NOT2/CDC36 | CNOT2 | ReginaNOT2 | Unknown but contributes to stabilization of the complex and RNA substrate recruitment |
| NOT3 | Not present | Not present | Unknown but contributes to stabilization of the complex and RNA substrate recruitment |
| NOT5 | CNOT3 | NOT3 | Interaction with ribosomes |
| NOT4/MOT2/SIG1 | CNOT4 | NOT4 | Ubiquitin E3-ligase activity |
| CCR4 | CNOT6, CNOT6L | Twin, CCR4 | Deadenylase |
| CAF1 | CNOT7, CNOT8 | P0P2, CAF1 | Deadenylase |
| CAF40 | CNOT9 (RQCD1) | RCD1 | Transcriptional cofactor |
| Not present | CNOT10 | NOT10 | Unknown but contributes to stabilization of the complex and RNA substrate recruitment |
| Not present | CNOT11 (C2orf29) | NOT11 | Unknown but contributes to stabilization of the complex and RNA substrate recruitment |
| CAF130 | Not present | Not present | Unknown |
| Not present | TNKS1BP1 (Tab182) | Not present | Multifunctional |