Figure 2.

Annexin A3 (ANXA3) upregulation in neutrophils in response to septic plasma correlates with clinical outcomes. The three independent datasets contributed by Khaenam et al. (GSE49755/56/57) were combined after normalizing each to the average of its respective controls (neutrophil cultures with medium only). Other conditions included cells exposed to LPS or to plasma from: (i) uninfected controls; (ii) septic patients who responded to treatment and eventually recovered; and (iii) septic patients who did not improve and ultimately succumbed to sepsis. The level of statistical significance is indicated on the plot: t‐test P‐values < 0·01**, < 0·001***.