Figure 1.

Plasma proteomic analyses and functional annotations identifying changes in differentially abundant proteins over the first week of drug administration. (A) Time-dependent up- and downregulation of differentially abundant proteins compared with the start of drug administration; T₀. The number of proteins altered at each time point is shown above each time point. (B) Venn diagram of proteins differentially abundant at T₁, T₄, and T₁₀ vs. T₀. (C) Gene ontology terms of proteins differentially up- and downregulated at T₁, T₄, and T₁₀ vs. T₀.